Redefining cancer as a metabolic disease: Dr Thomas Seyfried

Regardless of astonishing advances in science and expertise over the past a number of many years, most cancers stays one of many main causes of loss of life worldwide, with an estimated 9.96 million individuals dying from most cancers in 2020. Dr Thomas Seyfried, a professor at Boston Faculty and a outstanding researcher and professor within the area of most cancers biology and metabolic remedy, believes this can be a results of a misunderstanding as to what most cancers is. Over a decade in the past, Seyfried, a trailblazer within the enviornment of conquering most cancers, revealed his groundbreaking guide Most cancers as a Metabolic Illness: On the Origin, Administration, and Prevention of Most cancers, which offered intensive data displaying that most cancers might be greatest outlined as a mitochondrial metabolic illness fairly than as a genetic illness. This concept has unbelievable implications for the event of latest non-toxic most cancers therapies. In an interview with Dr Seyfried, he defined the virtues of this idea, the dogmatic ideology that’s suppressing its growth in mainstream medication, and the way the present most cancers therapy is killing sufferers. A shocking interview with thought-provoking revelations. – Nadya Swart

See timestamped subjects under:

00:00 Dr Thomas Seyfried on the report launched on 25 Might of a examine by a group of worldwide researchers, of which he was a co-author, which discovered a non-toxic mixture that destroys the 2 main cells in glioblastoma
09:01 On the metabolic therapies which are capable of deal with most cancers
11:50 On the prevailing genetic concept of most cancers as a illness and the contrasting mitochondrial metabolic definition of most cancers
14:19 On mitochondria
18:11 On the misunderstanding that each most cancers is totally different and the prevalence of a number of fashionable sicknesses being thought to be metabolic ailments  
22:42 On the systemic drawback of docs not being allowed to advocate various therapies for most cancers
24:43 On Otto Warburg’s concept on the origin of most cancers
26:28 On ideological dogma within the medical career
29:58 On the challenges dealing with the metabolic remedy most cancers therapy trials going forward
33:36 On the funding of those trials
36:14 On his really useful preventative measures in respect of creating most cancers
38:28 On whether or not there are any components, other than carcinogens and irritation, and many others., that may induce most cancers
44:47 On the metabolic remedy most cancers therapy trial
47:06 On whether or not metabolic therapies needs to be used alongside chemotherapy

Excerpts from the interview with Dr Thomas Seyfried

Dr Thomas Seyfried on the metabolic therapies that may deal with most cancers

The ketogenic weight loss plan, calorie restriction, or water-only fasting – any of those procedures decrease the blood sugar wanted to drive the tumour. They’re additionally powerfully anti-inflammatory. So many of those cancers are loaded with super quantities of irritation. The microenvironment is infected. All of that stuff might be considerably decreased. Folks say, nicely, water solely fasting, who can try this? Properly, you’ve got a selection. You may both try this, or you’ll be able to die from the tumour. I imply, you don’t have many choices. 

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Then again, a calorie-restricted ketogenic weight loss plan or any weight loss plan that lowers blood sugar and elevates ketones, which we now have proven – we’ve truly developed the glucose ketone index monitor to permit most cancers sufferers (not solely glioblastoma, virtually all cancers are very comparable, they’re all fermenters, all of them want glucose and glutamine), you’ve got a meter that can be utilized, the ketone mojo meter, to inform sufferers how low their blood sugar is and the way excessive their ketones are. And after they get into a specific zone, you’re going to be killing tumour cells. When you get into that zone, then we use glutamine-targeting medication. 

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One of many large challenges in managing mind cancers is delivering medication by means of what we name the blood-brain barrier. Once you put a affected person into therapeutic dietary ketosis, you’ll be able to simply ship small molecules to the tumour. We revealed papers displaying this. You don’t want some fancy chemical. You simply should put the affected person into therapeutic ketosis after which ship small portions of glutamine-targeting medication. You don’t even want loads. Very small quantities of those medication can be massively efficient when used with ketogenic metabolic remedy. 

So it’s a weight loss plan drug synergy to handle these cancers with out inflicting toxicity. It’s a pleasant factor, too. You don’t should have your hair fall out, have all these horrible nausea and vomiting and all this type of loopy stuff. I imply, sure, you’ll really feel hungry occasionally, however your physique will get justice. It adapts to this, and the tumour cells get hammered and begin shrivelling up and dying. And the sufferers dwell loads longer with a a lot greater high quality of life. And this would be the future. It simply takes time for individuals to grasp what I’m saying.

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On the prevailing genetic concept of most cancers as a illness

Proper now, when you go to the Nationwide Most cancers Institute in america, which is a part of the Nationwide Institutes of Well being, it says proper on their web site most cancers is a genetic illness brought on by mutations. I imply, nothing might be farther from the reality. It’s a dogmatic ideology. You realize, it’s a silent assumption that has been pushed into the brains not solely from the NCI but in addition all through the world. You go to England and Germany; all of them assume it’s a genetic illness. 

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I imply, we now have clearly proven this by means of nuclear switch experiments. I summarised dozens and dozens of experiments displaying that the mutations within the nucleus can’t be the drivers of dysregulated cell development, which is most cancers. Then they mentioned, nicely, these driver mutations are those which are chargeable for this. They even termed this. Not all of the mutations are dangerous, solely the drivers. Properly, now we’re realising all of us have giant numbers of driver mutations in cells that by no means turn out to be most cancers. 

And in addition, most cancers is extra of a contemporary drawback than it was previously. It was very uncommon to seek out in any of our people that adopted conventional methods of life. Our closest relative, the chimpanzee, by no means documented a case of breast most cancers in a feminine chimpanzee. But, in america, it has now changed coronary heart illness because the primary killer of ladies. The genetics of the chimp and [our genetics] are virtually the identical. Our Aboriginal ancestors are the identical as us, and most cancers is extraordinarily uncommon. So it’s an environmental drawback. 

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